Programa

16:00-16:10

Opening and welcome

Eduard Montanya, Scientific Director

16:10-18:00

SESSION 1

Chair: Josep Ribalta, Universitat Rovira i Virgili, IISPV, Tarragona & Olga Simó-Servat, Hospital Vall d'Hebron, Vall d'Hebron Research Institute (VHIR), Barcelona

16:10-16:40

STATE OF THE ART LECTURE

Favorable effects of nicotinamide supplementation on adiposity and inflammation in mice

Josep Julve, Instituto de Investigación del Hospital de la Santa Cruz y San Pablo, Barcelona

16:40-18:00

ORAL PRESENTATIONS

16:40 OP1

Lack of beneficial effect of iron tissue depletion on metabolic outcomes in women with polycystic ovary syndrome or idiopathic hyperandrogenism on standard treatment with combined oral contraceptives. A randomized clinical trial

Andrés Eduardo Ortiz-Flores1, Mª Angeles Martínez-García1,2, Lia Nattero-Chávez1,2,3, Elena Fernández-Durán1,2, Quintero-Tobar, A.1,2 Héctor F. Escobar-Morreale1,2,3, Manuel Luque- Ramírez M1,2,3

1 Diabetes, Obesity, and Human Reproduction Research Group, Instituto Ramón y Cajal de Investigación Sanitaria, CIBERDEM; 2 Department of Endocrinology and Nutrition, Hospital Universitario Ramón y Cajal, Madrid; 3 University of Alcalá, Alcalá de Henares, Madrid

16:55 OP2

Relationship between serum vascular endothelium growth factor b levels and the development of metabolic syndrome in the [email protected] study

Eva García-Escobar1,2, Ana Lago-Sampedro1,2, Sergio Valdés1,2, Natalia Colomo1,2, Cristina Maldonado1,2, Luis Castaño 1, Javier Chaves1, Alfonso Calle1, Josep Franch1, Elías Delgado1, Federico Soriguer3, Gemma Rojo-Martínez1,2, Sara García-Serrano1,2

1CIBERDEM; 2Biomedical Research Institute of Malaga (IBIMA), Endocrinology and Nutrition Department, Regional University Hospital of Malaga, Malaga; 3Science Academy of Malaga, Málaga

17:10 OP3

Effects of Glucagon-like peptide-1 (GLP-1) in Diabetes-Induced Retinal Abnormalities: Involvement of Oxidative Stress

Hugo Ramos1,2, Cristina Hernández C1,2,3, Joel Sampedro 1, Jordi Huerta1,2, Rafael Simó1,2,3* Patricia Bogdanov1,2*

1Diabetes and Metabolism Research Unit, Vall d’Hebron Research Institute, Barcelona; 2CIBERDEM; 3Department of Medicine, Universitat Autònoma de Barcelona

17:25 OP4

Subclinical macular edema and diabetic retinopathy: two entities evolving in parallel?

Olga Simó-Servat1, Efraín Cordero-Vázquez1, Alejandra Planas1, Marc Ribas1, Eva Sanz1, Helena Brossa2, José García-Arumí2, Cristina Hernández1, Rafael Simó1

1Endocrinology Department, Vall d'Hebron Hospital; Diabetes and Metabolism Unit, Vall d'Hebron Research Institute (VHIR); 2Ophtalmology Department, Vall d'Hebron Hospital

17:40 OP5

Seasonal Stochastic Local Modelling: a new framework for accuracy improvement of glucose prediction in type 1 diabetes

Eslam Montaser1, José Luis Díez1,2, Jorge Bondia1,2

1Universitat Politècnica de València, València; 2CIBERDEM

18:15-19:20

SESSION 2 – RAPID COMUNICATIONS

Room 1

Chair: Héctor Escobar, Hospital Universitario Ramón y Cajal, Universidad de Alcalá, Instituto Ramón y Cajal de Investigación Sanitaria IRYCIS, Madrid & Laura Piqueras, Institute of Health Research-INCLIVA, University of Valencia, Valencia

18:15 RC1

Influence of obesity and sex hormones on surrogate markers of gut permeability after glucose, lipid and protein oral challenges

Mª Ángeles Martínez-García, María Insenser, Alejandra Quintero-Tobar, Elena-Fernández-Durán, Manuel Luque-Ramírez, Héctor F. Escobar-Morreale.

Diabetes, Obesity and Human Reproduction Research Group, Department of Endocrinology & Nutrition, Hospital Universitario Ramón y Cajal & Universidad de Alcalá & Instituto Ramón y Cajal de Investigación Sanitaria IRYCIS & CIBERDEM, Madrid

18:22 RC2

Acute-phase glycoprotein profile responses to different 1 oral macronutrient challenges: Influence of sex, functional hyperandrogenism and obesity.

Samuel Moncayo, María Insenser, M. Ángeles Martínez-García, Rocío Fuertes-Martín, Núria Amigó-Grau, Francisco Álvarez-Blasco, Manuel Luque-Ramírez, Xavier Correig-Blanchar, Héctor F. Escobar-Morreale

Diabetes, Obesity and Human Reproduction Research Group, Hospital Universitario Ramón y Cajal & Universidad de Alcalá & Instituto Ramón y Cajal de Investigación Sanitaria IRYCIS & CIBERDEM, Madrid. BiosferTeslab SL; Universitat Rovira i Virgili, IISPV; CIBERDEM, Reus. Metabolomics platform, DEEEAUniversitat Rovira i Virgili, IISPV; CIBERDEM, Tarragona.

18:29 RC3

Gut Microbiota in Non-Obese Adolescent Girls with Polycystic Ovary Syndrome: Effects of Randomized Treatments

Cristina Garcia-Beltran1,2, Rita Malpique1,2, Belen Carbonetto3, Pedro González-Torres3, Desirée Henares4,5, Pedro Brotons4,5,6, Carmen Muñoz-Almagro4,5,6, Abel López-Bermejo7, Francis de Zegher8, Lourdes Ibáñez1,2

1 Endocrinology Department, Pediatric Research Institute Hospital Sant Joan de Déu, University of Barcelona, Esplugues, Barcelona; 2 CIBERDEM; 3 Microomics Systems S.L., Barcelona Biomedical Research Park (PRBB), Barcelona; 4 Molecular Microbiology Department, Pediatric Research Institute Hospital Sant Joan de Déu, Esplugues, Barcelona; 5 CIBERESP; 6 School of Medicine, Universitat Internacional de Catalunya, Barcelona; 7 Pediatric Endocrinology Research Group, Girona Institute for Biomedical Research (IDIBGI) and Dr. Josep Trueta Hospital, Girona, Spain; 8 Department of Development & Regeneration, University of Leuven, Leuven, Belgium.

18:36 RC4

Upregulation of CCL22 is related to insulin resistance in morbidly obese subjects

Luisa Hueso1,3, Rebeca Ortega1,3, Esther Benito1,2,5, Marta Peiró 1,5 Joaquín Ortega4, Miguel Civera1,2, Maria-Jesus Sanz1,3,5, José T Real1,2,5, Laura Piqueras1,3,5

1Institute of Health Research-INCLIVA, Valencia; 2Endocrinology and Nutrition Service, University Clinic Hospital of Valencia, Valencia; 3Department of Pharmacology, Faculty of Medicine, University of Valencia, Valencia; 4Surgery Service, University Clinic Hospital of Valencia, Valencia; Department of Surgery, University of Valencia, Valencia; 5CIBERDEM

18:43 RC5

Up-regulation of nuclear retinoid‐related orphan receptor RORα in adipose tissue from diabetic obese patients.

Rebeca Ortega1,3, Luisa Hueso1,3, Esther Benito1,2,5, Marta Peiró 1,5 Joaquín Ortega4, Miguel Civera1,2, Maria-Jesus Sanz1,3,5, Laura Piqueras1,3,5, José T Real1,2,5

1Institute of Health Research-INCLIVA, Valencia; 2Endocrinology and Nutrition Service, University Clinic Hospital of Valencia, Valencia; 3Department of Pharmacology, Faculty of Medicine, University of Valencia, Valencia; 4Surgery Service, University Clinic Hospital of Valencia, Valencia, Spain; Department of Surgery, University of Valencia, Valencia; 5CIBERDEM

18:50 RC6

Mediterranean Diet and healthy eating in subjects with prediabetes of the Mollerussa prospective cohort study, a semi-rural area

Mireia Falguera1,2, Minerva Granado-Casas3,5, Maria Belén Vilanova2,4, Jordi Real5,6, Neus Miró7, Cristina Cebrian8, Àngels Molló9, Manel Mata-Cases5,6,10, Josep Franch-Nadal5,6,11, Esmeralda Castelblanco6,12, Didac Mauricio6,12,13

1 Primary Health Care Centre Cervera, Gerència d'Atenció Primaria, Institut Català de la Salut, Lleida; 2 Department of Medicine, University of Lleida & Biomedical Research Institute of Lleida (IRBLleida), Lleida; 3Department of Endocrinology & Nutrition, University Hospital Germans Trias I Pujol & Health Sciences Research Institute, Badalona; 4 Primary Health Care Centre Igualada Nord, Gerència d'Atenció Primaria, Institut Català de la Salut, Lleida; 5 DAP-Cat Group, Unitat de Suport a la Recerca Barcelona, Fundació Institut Universitari per a la Recerca a l'Atenció Primària de Salut Jordi Gol i Gurina (IDIAPJGol), Barcelona; 6CIBERDEM, Barcelona; 7 Primary Health Care Centre Tàrrega, Gerència d’Atenció Primaria, Institut Català de la Salut, Lleida; 8Primary Health Care Centre Mollerussa, Gerència d'Atenció Primaria, Institut Català de la Salut, Lleida; 9Primary Health Care Centre Guissona, Gerència d'Atenció Primaria, Institut Català de la Salut, Lleida; 10 Primary Health Care Centre La Mina, Gerència d'Atenció Primària Barcelona, Institut Català de la Salut, Barcelona; 11 Primary Health Care Centre Raval Sud, Gerència d'Atenció Primaria Barcelona, Institut Català de la Salut, Barcelona; 12 Department of Endocrinology & Nutrition, Hospital de la Santa Creu i Sant Pau & Institut d’Investigació Biomédica Sant Pau (IIB Sant Pau),Barcelona;13 Faculty of Medicine, University of Vic (UVIC/UCC), Vic

18:57 RC7

Fatty Acid Binding Protein 4 is associated with Fatty Liver in metabolic patients

Ricardo Rodríguez-Calvo, Juan Moreno, Josefa Girona, Daiana Ibarretxe, Neus Martínez-Micaelo,Nuria Plana, Lluís Masana

Vascular Medicine and Metabolism Unit, Research Unit on Lipids and Atherosclerosis, “Sant Joan” University Hospital, Universitat Rovira i Virgili, Institut de Investigació Sanitaria Pere Virgili (IISPV), Reus; CIBERDEMic

19:04 RC8

Atherogenic dyslipidemia, but not hyperglycemia, is an independent risk factor for liver fibrosis in subjects with type 2 diabetes mellitus and NAFLD: A population –based study

Nuria Alonso1,4,7, María Teresa Julián1, Guillem Pera2,3, Berta Soldevila1,4, Llorenç Caballería2,3, Josep Julve5,6,7, Carlos Puig1, Rosa Morillas3,8, Pere Torán2,3, Carmen Expósito2,3, Manel Puig- Domingo1,4,7, Esmeralda Castelblanco5,7, Josep Franch-Nadal7,9Dídac Mauricio5,7,10

1Department of Endocrinology and Nutrition Department, Hospital Germans Trias I Pujol, Badalona, Barcelona; 2Unitat de Suport a la Recerca Metropolitana Nord, Fundació Institut Universitari per a la Recerca a l'Atenció Primària de Salut Jordi Gol i Gurina (IDIAPJGol), Mataró; 3CIBEREHD, Barcelona; 4Department of Medicine, Autonomous University of Barcelona (UAB), Barcelona; 5Hospital de la Santa Creu i Sant Pau, & Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau), Barcelona; 6Departament de Bioquímica y Biología Molecular, Universitat Autònoma de Barcelona, Barcelona; 7CIBERDEM; 8Hepatology Department, Hospital Germans Trias I Pujol, Badalona, Barcelona; 9Primary Health Care Center Raval Sud, Gerència d'Atenció Primaria, Institut Català de la Salut, Barcelona; 10Department of Endocrinology and Nutrition, Hospital de la Santa Creu i Sant Pau; Institut d'Investigació Biomédica Sant Pau (IIB Sant Pau), Barcelona

19:11 RC9

Differential DNA Methylation Profile in Infants Born Small-for-Gestational-Age: Association with Markers of Adiposity and Insulin Resistance from Birth to Age 24 Months

Marta Díaz1,2, Edurne Garde1,2, Abel López-Bermejo3, Francis de Zegher4, Lourdes Ibáñez1,2

1Institut Pediàtric Hospital Sant Joan de Déu, University of Barcelona, Esplugues, Barcelona; 2CIBERDEM; 3Department of Pediatrics, Dr. Josep Trueta Hospital, Girona, and Girona Institute for Biomedical Research, Girona; 4Department of Development & Regeneration, University of Leuven, Belgium

Room 2

Chair: Marcelina Parrizas, IDIBAPS, Barcelona & Sonia Fernández-Veledo, Hospital Universitario de Tarragona Joan XXIII, Instituto de Investigación Sanitaria Pere Virgili, Tarragona

18:15 RC10

miR-155 influences diabetic kidney disease by regulating SOCS1

Ignacio Prieto1, Luna Jiménez-Castilla1, Iolanda Lázaro2, Laura López-Sanz1, Susana Bernal- Uribe1, Mónica Flores-Muñoz3, Óscar López-Franco3, Jesús Egido1, Carmen Gómez-Guerrero1

1Renal, Vascular and Diabetes Research Lab, Instituto de Investigaciones Sanitarias-Fundación Jiménez Díaz (IIS-FJD), Universidad Autónoma de Madrid (UAM) and CIBERDEM; 2 Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS) and CIBEROBN; 3 Instituto de Ciencias de la Salud, Universidad Veracruzana, Xalapa, Veracruz, México

18:22 RC12

mTOR activation in diabetic and hypertensive cardiomyopathy

Tianyu Hang, Sagrario Corrales, Mikel Azkargorta, Malu Martínez-Chantar M, Jairo Lumpuy- Castillo, Jesus Egido, Oscar Lorenzo

IIS-Fundación Jiménez Díaz, UAM, Madrid; CIC-BioGune

18:29 RC13

Vitamin D Receptor overexpression prevents high fat diet-induced body weight gain and ameliorates insulin resistance

Laia Vilà1,3, Albert Ribera1,2,3, Sylvie Franckhauser1,3, Tura Ferré1,3, Meritxell Morró1,2,3, Ignasi Grass1,2,3, Maria Luisa Jaen1,2,3, Gemma Elias1,2,3, Estefanía Casana1,2,3, Fàtima Bosch1,2,3, Alba Casellas1,3

1Center of Animal Biotechnology and Gene Therapy; 2Department of Biochemistry and Molecular Biology, Universitat Autònoma de Barcelona, Bellaterra; 3CIBERDEM

18:36 RC14

Extra virgin olive oil reduced weight gain and improved insulin sensitivity in high fat diet-induced obese LDLr-/-.Leiden mice but did not attenuate steatohepatitis

Leticia Álvarez-Amor1,2, Amparo Luque Sierra1, Antonio Cárdenas1,2, Eloísa Andújar1, Mónica Pérez-Alegre1, Rocío Gallego-Durán3,4, Alejandro Martin-Montalvo1, Genoveva Berná1,2, Anabel Rojas1,2, Abdelkrim Hmadcha1,2, Robert Kleemann5, Manuel Romero-Gómez3,4, Franz Martín1,2

1CABIMER-UPO, Seville; 2CIBERDEM; 3Hospital Universitario Virgen del Rocío-IBiS, Seville; 4CIBEREHD; 5Department of Metabolic Health Research, Netherlands Organisation for Applied Scientific Research- TNO, Leiden, Netherlands; 6Department of Vascular Surgery, Leiden University Medical Centre, Leiden, Netherlands

18:43 RC15

Bace2 deficiency exacerbate body weight gain and hyperinsulinemia in mice fed a high fat diet

Daniela Díaz-Catalán1, Gema Alcarraz-Vizán1, Carlos Castaño1, Mario Vallejo2, Marcelina Párrizas1, Joan Marc Servitja1 and Anna Novials1

1 Diabetes and Obesity Research Laboratory. Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), CIBERDEM; 2Instituto de Investigaciones Biomédicas Alberto Sols, Consejo Superior de Investigaciones Científicas/Universidad Autónoma de Madrid, CIBERDEM

18:50 RC16

The inhibition of ATP-citrate lyase protects from non-alcoholic fatty liver disease in a model of high fat diet feeding

Alejandro Sola-García1, Manuel Aguilar-Diosdado2, Maria Ángeles Cáliz-Molina1, Vivian Capilla- González1, Franz Martin1,3,4, Benoit R. Gauthier1,3, Alejandro Martín-Montalvo1

1 Andalusian Center for Molecular Biology and Regenerative Medicine-CABIMER, Junta de Andalucia- University of Pablo de Olavide-University of Seville-CSIC, Seville; 2 Department of Endocrinology, Puerta del Mar Hospital Cádiz/ Department of Medicine, University of Cádiz; 3 CIBERDEM; 4 Department of Molecular Biology and Biochemistry Engineering, University Pablo de Olavide (UPO), Seville

18:57 RC17

Characterization and study of Goblet cells involved in mucus layer secretion in a rat model of metabolic syndrome associated to catch-up growth

Paula Martínez Oca1,2; Tamara Fernández Marcelo1,2; Alicia Sánchez Roncero1,2; María Ángeles Martín2,3; Fernando Escrivá1,2; Elisa Fernández Millán1,2; Carmen Álvarez Escolá1,2

1 Department of Biochemistry and Molecular Biology, Faculty of Pharmacy, Complutense University of Madrid; 2 CIBERDEM; 3 Department of Metabolism and Nutrition, Institute of Food Science and Technology and Nutrition (ICTAN), Consejo Superior de Investigaciones Científicas (CSIC), Madrid

19:04 RC18

PTP1B deficiency protects male mice against insulin resistance but not thermogenic alterations upon Olanzapine intraperitoneal treatment

Vítor Ferreira1,2, Patrícia Rada1,2, Diana Grajales1,2, Irma García-Martinez1,2, Patricia Vazquez- Perez1,2, Ángela M. Valverde1,2

1IIBm Alberto Sols (CSIC-UAM), Madrid; 2CIBERDEM

14:45-15:45

SIMPOSIO SATÉLITE CIBERDEM/MSD 2020

Bienvenida: Eduard Montanya, Servicio de Endocrinología y Nutrición, Hospital Universitario de Bellvitge, Barcelona, Director Científico CIBERDEM

Moderador: Javier Escalada, Jefe de servicio de Endocrinología, Clínica Universitaria de Navarra (CUN), Pamplona

Incidencia y regresión del síndrome metabólico en una muestra representativa de la población española: resultados de la cohorte del estudio [email protected]

Nuria García de la Torre, Servicio de Endocrinología y Nutrición, Hospital Clínico Universitario San Carlos, Madrid, CIBERDEM

Ver sesión

16:00-18:00

SESSION 3

Chair: Deborah Burks, Centro de Investigación Príncipe Felipe, Valencia & Ivan Quesada, Instituto de Investigación, Desarrollo e Innovación en Biotecnología Sanitaria de Elche (IDiBE), Elche

16:00-16:30

STATE OF THE ART LECTURE

Circadian clocks and metabolic entrainment: Do the eyes talk to the liver?

Mario Vallejo, Instituto de Investigaciones Biomédicas Alberto Sols, CSIC, Madrid

16:30-17:45

ORAL PRESENTATIONS

16:30 OP6

Effects of aging on beta-cell mass and function

Eva Tudurí1,2, Lucía Almagro2, Sergi Soriano2,3, Anabel García-Heredia2, Ángel Nadal1,2, Iván Quesada1,2

1CIBERDEM; 2Instituto de Investigación, Desarrollo e Innovación en Biotecnología Sanitaria de Elche (IDiBE), Elche; 3Departamento de Fisiología, Genética y Microbiología, Universidad de Alicante

16:45 OP7

Endoplasmic reticulum stress contributes to the loss of β-cell identity in human pancreatic islets treated with glibenclamide

Claudia Fernández1,2,3, Noèlia Téllez1,2,3, Víctor Gutiérrez2, Kevin Rivera2, Montserrat Nacher1,2,4, Eduard Montanya1,2,3,4

1CIBERDEM; 2Bellvitge Biomedical Research Institute, IDIBELL; 3University of Barcelona; 4Endocrine Unit, Hospital Universitari Bellvitge, Barcelona

17:00 OP8

LRH-1/NR5A2 Specifies BL001-Mediated -cell Survival and Trans-Regeneration

Cobo-Vuilleumier, N1, Martín-Vazquez, E1, Lorenzo, PI1, Irene Díaz-Contreras1,2, Martín F1,2, Gerdes, JM3, Ferrer, J4,2, Romero-Zerbo SY5,2, García-Fernández M6, Francisco Javier Bermúdez- Silva5,2, Gannon, M7, Collombat, P8, Benoit R Gauthier1,2

1Andalusian Center for Molecular Biology and Regenerative Medicine, Sevilla, 2CIBERDEM; 3Helmholtz Zentrum München, Neuherberg, Germany; 4The Barcelona Institute of Science and Technology, Barcelona; 5Instituto de Investigación Biomédica de Málaga-IBIMA, UGC Endocrinología y Nutrición. Hospital Regional Universitario de Málaga, Málaga; 6Departamento de Fisiología, Facultad de Medicina, Universidad de Málaga, Málaga; 7Vanderbilt University Medical Center, Nashville, TN, USA; 8Nice Sophia Antipolis University, Nice, France

17:15 OP9

GPR40 mediated amplification of glucose-dependent insulin secretion requires expression of Alx3

Mercedes Mirasierra, Paula Nuevo-Gutierrez, Mario Vallejo

Instituto de Investigaciones Biomédicas Alberto Sols, CSIC/Universidad Autónoma de Madrid, CIBERDEM

17:30 OP10

Inhibition of insulin secretion by second-generation antipsychotics might mediate prediabetes development

Diana Grajales1,2, Vázquez P1,2, Ruíz-Rosario, M 3, Ferreira, V 1,2, Tudurí, E2,4, Cigudosa, J3, Quesada, I2,4, Tirosh, B5, Leibowitz, G6, Valverde, ÁM1,2

1IIBm Alberto Sols (CSIC-UAM), Madrid; 2CIBERDEM; 3NIM Genetics, Madrid; 4Instituto de Investigación, Desarrollo e Innovación en Biotecnología Sanitaria de Elche (IDiBE), Elche; 5The Institute of Drug Research, School of Pharmacy, The Hebrew University of Jerusalem, Israel; 6Endocrinology and Metabolism Service, Department of Medicine, Hadassah-Hebrew University Medical Center, Jerusalem, Israel

18:00-19:05

SESSION 4 – RAPID COMUNICATIONS

Room 1

Chair: Patricia Rada, Instituto de Investigaciones Biomédicas Alberto Sols (CSIC-UAM), Madrid & Manuel Vázquez, University of Barcelona, Institute of Biomedicine of the University of Barcelona (IBUB), Research Institute-Hospital Sant Joan de Déu, Barcelona

18:00 RC19

Nuclear coactivator RAP250 modulates adiposity and the metabolic activity of brown adipose tissue

Manuela Sánchez-Feutrie1,2,3†, Sónia Rosa Veiga1,2,3†, Andrea Rodgers-Furones1,2, Montserrat Romero1,2,3, Alba Sabaté-Pérez1,2,3, Luis Rodrigo Cataldo1, Hans Burghardt1,2,3, David Sebastián1,2,3, Mònica Sabater-Masdeu4,5, José María Moreno-Navarrete4,5, Francisco Ortega4,5, Wifredo Ricart4,5, Natàlia Plana1, Vanessa Hernández1, Laura Isabel Alcaide1, José Juan Marín 6, Manuel Palacín1,2,7, Remy Burcelin8, Joan Vendrell9,10, José Manuel Fernández-Real4,5, Per Antonson11, Jan-Ake Gustafsson11,12, Antonio Zorzano1,2,3

1Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Barcelona; 2 Departament de Bioquímica i Biomedicina Molecular, Facultat de Biologia, Universitat de Barcelona, 3 CIBERDEM; 4 CIBEROBN; 5 Department of Diabetes, Endocrinology and Nutrition, Institut d'Investigació Biomèdica de Girona (IdIBGi), Hospital of Girona 'Dr Josep Trueta', Girona; 6 Experimental Hepatology and Drug Targeting, CIBEREHD, IBSAL, University of Salamanca; 7 CIBERER; 8 UMR 5018 CNRSUPS and IFR 31, Rangueil Hospital, L1 Bldg, BP 84225 Toulouse 31432 Cedex 4, France; 9 Department of Endocrinology, Hospital Joan XXIII, Rovira i Virgili University, Tarragona; 10 Institut d'Investigació Sanitaria Pere Virgili (IISPV), Tarragona; 11 Department of Biosciences and Nutrition, Karolinska Institutet, Novum, SE-141 83, Huddinge, Sweden; 12 Center for Nuclear Receptors and Cell Signaling, Department of Biology and Biochemistry, University of Houston, Houston, TX, USA; †MSF and SRV contributed equally

18:07 RC20

Role of Mfn-1 in brown adipose tissue during cold-challenge

Beatriz Jiménez, Gema García, Patricia Marqués, Jesús Burillo, Carlos González, Carlos Guillén, Manuel Benito

Diabetes and Obesity Group, Biochemistry and Molecular Biology Department; Pharmacy School, UCM, CIBERDEM

18:14 RC21

TP53INP2 regulates energy balance through brown adipose tissue thermogenesis

Alba Sabaté-Pérez1,2,3, Montserrat Romero1 2,3, Sam Virtue4, Antonio Vidal-Puig4,5, Xavier Testar1,3, Antonio Zorzano1,2,3

1CIBERDEM, Barcelona; 2Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Barcelona; 3Departament of Biochemistry and Molecular Biomedicine, Faculty of Biology, University of Barcelona; 4Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke's Hospital, University of Cambridge, Cambridge, CB2 0QQ, UK; 5Wellcome

18:21 RC22

Resveratrol enhanced cold-induced thermogenesis through a differential browning effect on the adipose organ in a mouse model showing atrophied interscapular adipose tissue: a therapeutic approach

Manuel Benito1,2,3 Patricia Marqués1, Helena Martínez1, Beatriz Jiménez1,2, Jesús Burillo1,2,3, Carlos González1, Gema García1,2, Carlos Guillén1,2,3

1Department of Biochemistry and Molecular Biology, School of Pharmacy, Complutense University of Madrid; 2CIBERDEM, 3MOIR2: Mechanism of Insulin Resistance, General Direction of Universities and Investigation (CCMM), Madrid

18:28 RC23

Role of TP53INP2 in autophagy and apoptosis cross-talk

Saška Ivanova1,2,3, Antonio Zorzano1,2,3

Institute for Research in Biomedicine (IRB Barcelona), Barcelona Institute of Science and Technology (BIST), Barcelona; 2 CIBERDEM, Barcelona; 3 Departamento de Bioquimica i Biomedicina Molecular, Facultat de Biologia, Universitat de Barcelona

18:35 RC24

Mobilization of Arachidonic Acid and Adrenic Acid in Macrophages by Two Different Phospholipase A2s

Patricia Monge, Álvaro Garrido, María A. Balboa, Jesús Balsinde.

Instituto de Biología y Genética Molecular, Consejo Superior de Investigaciones Científicas (CSIC), Valladolid, CIBERDEM.

18:42 RC25

Role of the succinate/SUCNR1 axis in the physiopathology of NAFLD

Patricia Rada1,2*, Victoria Ceperuelo-Mallafré 2,3*, Enrique Calvo 2,3, M. Mar Rodríguez 2,3, Catalina Núñez-Roa 2,3, Teresa Villanueva 2,3, Joan Vendrell 2,3, Ángela M. Valverde 1,2 and Sonia Fernández-Veledo 2,3

1 Instituto de Investigaciones Biomédicas “Alberto Sols” (CSIC-UAM), Madrid; 2 CIBERDEM; 3 Unitat de Recerca, Hospital Universitari de Tarragona Joan XXIII, Institut d´Investigació Sanitària Pere Virgili, Tarragona *Equal contributors

18:49 RC26

Inhibition of protein tyrosine phosphatase 1B protects against lipotoxicity in liver progenitor oval cells

Inés Barahona1,2, M. Pilar Valdecantos1,2, Patricia Rada1,2, Alma Astudillo2,3, Jesús Balsinde2,3, Aránzazu Sánchez4, Ángela M. Valverde1,2

1IIBm Alberto Sols (CSIC-UAM), Madrid, 2CIBERDEM; 3Instituto de Biología y Genética Molecular (CSIC-UVA), Valladolid; 4Departamento de Bioquímica y Biología Molecular, UCM, Madrid

18:56 RC27

Effect of the hepatocyte-derived lipotoxic extracellular vesicles in liver inflammation in non-alcoholic fatty liver disease

Rosa Alén1, Irma Garcia-Martinez1, Laura Pereira2, Jesús Balsinde2, Manuel Izquierdo1, Ángela M. Valverde1.

1Instituto de Investigaciones Biomédicas Albero Sols, CSIC/UAM, Madrid; 2 Instituto de Biología y Genética Molecular, CSIC/UVa, Valladolid

Room 2

Chair: Sonia Gaztambide, Biocruces Bizkaia Health Research Institute, Cruces University Hospital, University of the Basque Country, Bizkaia & Oscar Lorenzo, IIS-Fundación Jiménez Díaz, UAM, Madrid; CIC-BioGune

18:00 RC28

Regular insulin added to total parenteral nutrition vs subcutaneous glargine in non-critically ill diabetic inpatients, a multicentre randomized clinical trial: INSUPAR trial

Cristina Maldonado-Araque1,2,3, Jose Abuín1,2, María J. Tapia1, Rafael López4, Sandra Herranz5, Jose M. García-Almeida6, Katherine García-Malpartida7, Mercedes Ferrer8, Emilia Cancer9, Luis M. Luengo-Pérez10, Julia Álvarez11, Carmen Aragón12, María J. Ocón13, Álvaro García-Manzanares14, Irene Bretón15, Pilar Serrano-Aguayo16, Natalia Pérez-Ferre17, Juan J. López-Gómez18, Josefina Olivares19, Carmen Arraiza20, Cristina Tejera21, Jorge D. Martín22, Sara García23, Ángel L. Abad24, María R. Alhambra25, Ana Zugasti26, Juan Parra27, Sara Torrejón28, María J. Tapia1 Gabriel Olveira1,2,3

1 Unidad de Gestión Clínica de Endocrinología y Nutrición, Hospital Regional Universitario de Málaga, Instituto de Investigación Biomédica de Málaga (IBIMA); 2 Universidad de Málaga; 3 CIBERDEM; 4 Servicio de Endocrinología y Nutrición, Hospital Universitario de Bellvitge, L'Hospitalet de Llobregat; 5 Servicio de Endocrinología y Nutrición, Hospital Universitario de Guadalajara; 6 Servicio de Endocrinología y Nutrición, Hospital Universitario Virgen de la Victoria, Málaga; 7 Servicio de Endocrinología y Nutrición, Hospital Universitario y Politécnico La Fe, Valencia; 8 Servicio de Endocrinología y Nutrición, Hospital Clínico Universitario Virgen de la Arrixaca, Murcia; 9 Sección de Endocrinología y Nutrición, Hospital Universitario de Fuenlabrada; 10 Servicio de Endocrinología y Nutrición, Hospital Universitario de Badajoz; 11 Servicio de Endocrinología y Nutrición, Hospital Universitario Príncipe de Asturias, Madrid; 12 Servicio de Endocrinología y Nutrición, Hospital Universitario Fundación Jiménez Díaz, Madrid; 13 Servicio de Endocrinología y Nutrición, Hospital Universitario Lozano Blesa, Zaragoza; 14 Servicio de Endocrinología y Nutrición, Hospital General La Mancha Centro, Alcázar de San Juan; 15 Servicio de Endocrinología y Nutrición, Hospital Universitario Gregorio Marañón, Madrid; 16 Unidad de Endocrinología y Nutrición, Hospital Universitario Virgen del Rocío, Sevilla; 17 Servicio de Endocrinología y Nutrición, Hospital Clínico San Carlos, Madrid; 18 Servicio de Endocrinología y Nutrición, Hospital Clínico Universitario de Valladolid; 19 Servicio de Endocrinología y Nutrición, Hospital Universitario Son Llatzer, Illes Balears; 20 Servicio de Endocrinología y Nutrición, Complejo Hospitalario de Jaén; 21 Servicio de Endocrinología y Nutrición, Complejo Hospitalario Universitario de Ferrol, A Coruña; 22 Servicio de Endocrinología y Nutrición, Hospital Universitario Severo Ochoa, Leganés, Madrid; 23 Servicio de Endocrinología y Nutrición, Complejo Asistencial Universitario de León; 24 Unidad de Nutrición y Sección de Endocrinología, Hospital General Universitario de Alicante; 25 Servicio de Endocrinología y Nutrición, Hospital Universitario Reina Sofía, Córdoba; 26 Servicio de Endocrinología y Nutrición, Complejo Hospitalario de Navarra; 27 Servicio de Endocrinología y Nutrición, Hospital de Mérida, Badajoz; 28 Servicio de Endocrinología y Nutrición, Hospital de Sant Joan Despí Moisés Broggi, Barcelona.

18:07 RC29

Lipid Biomarkers as Predictors of Diastolic Dysfunction in Diabetes with Poor Glycemic Control

1Jairo Lumpuy-Castillo, 2Dina Khedr, 2Noha Musa , 1,3Óscar Lorenzo

1Laboratory of Diabetes Research, Instituto de Investigaciones Sanitarias-Fundación Jiménez Díaz, Universidad Autónoma, Madrid; 2Pediatric Diabetes, Endocrine and Metabolism Unit, Children Hospital, Cairo University, Cairo, Egypt; 3CIBERDEM

18:14 RC30

Lipidomic profile and subclinical carotid atherosclerosis in diabetes mellitus

Maria Barranco1,8,9,10, Esmeralda Castelblanco1,2, Paola Quifer1,2, Oscar Yanes2,3, Ralf Weber4, Emilio Ortega5,6, Nuria Alonso2,7, Didac Mauricio1,2

1Sant Pau Biomedical Research Institute (IIB Sant Pau), Hospital de la Santa Creu i Sant Pau, Endocrinology and Nutrition, Barcelona; 2CIBERDEM; 3Institute of Health Research Pere Virgili (IISPV) & University Pere i Virgili, Metabolomics Platform, Reus; 4Phenome Centre Birmingham and School of Biosciences, University of Birmingham, Bioinformatics, Birmingham, UK; 5Institut d'Investigacions Biomèdiques August Pi i Suñer, Hospital Clinic, Endocrinology and Nutrition, Barcelona; 6Center for Biomedical Research on Physiopathology of Obesity and Nutrition, CIBEROBN, Madrid; 7Institute for Health Science Research Germans Trias i Pujol (IGTP), University Hospital and Health Research Institute Germans Trias i Pujol, Endocrinology and Nutrition, Badalona; 8B2SLab, Departament d'Enginyeria de Sistemes, Automàtica i Informàtica Industrial, Universitat Politècnica de Catalunya, Barcelona; 9 CIBER-BBN, Madrid; 10Institut de Recerca Pediàtrica Hospital Sant Joan de Déu, Esplugues de Llobregat, Barcelona

18:21 RC31

Relation between skin AGEs and the coronary artery calcium score: results of the PRECISED study

Alejandra Planas1 Olga Simó-Servat1, Jordi Bañeras2, Cristina Hernández1, Ignacio Ferreira2 and Rafael Simó1

1 Diabetes and Metabolism Research Unit, Endocrinology Department, Vall d'Hebron Research Unit, Vall d'Hebron Hospital, Autonomous University of Barcelona, Barcelona, CIBERDEM; 2 Cardiology Research Group, Cardiology Department, Vall d'Hebron Research Institute, Vall d'Hebron Hospital, Autonomous University of Barcelona

18:28 RC32

Addition of probiotics to anti-obesity therapy by percutaneous electrical stimulation of dermatome T6. A pilot study

1Jairo Lumpuy-Castillo, 1Tianyu Hang, 1Marta Crespo-Yanguas, 2,3Jaime Ruiz-Tovar, 1,4Óscar Lorenzo

1Laboratory of Diabetes and Vascular pathology. Instituto de Investigaciones Sanitarias-Fundación Jiménez Díaz. Universidad Autónoma, Madrid; 2Obesity Unit. Clínica Garcilaso, Madrid, 3Department of Health Sciences, Universidad Rey Juan Carlos, Madrid; 4CIBERDEM

18:35 RC33

Incidence of diabetes mellitus in the Basque country and associated risk factors: reassessment of an adult population after seven years of follow-up

Inés Urrutia1,2, Alicia Martín-Nieto1,3, Rosa Martínez1,2, J Oriol Casanovas-Marsal1, Anibal Aguayo1,2, Juan del Olmo4, Eunate Arana1, Elsa Fernandez-Rubio1,3, Luis Castaño1,2*, Sonia Gaztambide1,2,3* on behalf of the Diabetes Epidemiology Group

1Biocruces Bizkaia Health Research Institute, Cruces University Hospital, University of the Basque Country UPV/EHU, Bizkaia; 2CIBERDEM, CIBERER; 3Endocrinology and Nutrition Department, Cruces University Hospital, Bizkaia; 4Clinical Chemistry Laboratory, Cruces University Hospital, Bizkaia

18:42 RC34

After metformin: Analysis of the effectiveness of second oral glucose-lowering therapy in routine clinical practice from the Mediterranean area

Bogdan Vlacho1, Manel Mata-Cases1, 2, Joan Antoni Vallès-Callol1, Jordi Real1, 2, Xavier Mundet-Tudurí1, 4, Kamlesh Khunti5, Dídac Mauricio1, 2,3, Josep Franch-Nadal1, 2

1DAP‑Cat group, Unitat de Suport a la Recerca Barcelona, Fundació Institut Universitari per a la Recerca a l'Atenció Primària de Salut Jordi Gol i Gurina (IDIAPJGol), Barcelona; CIBERDEM); 3Department of Endocrinology and Nutrition, Hospital Universitari de la Santa Creu i Sant Pau, Spain; 4 Departament of Medicine, Universitat Autònoma de Barcelona, Bellaterra; 5Diabetes Research Centre, University of Leicester, Leicester, UK

18:49 RC35

Reduction in hypoglycemic frequency during and after short High Intensity Interval Training in type 1 diabetes individuals.

Serafín Murillo, Laura Brugnara, Anna Novials.

IDIBAPS, Barcelona; CIBERDEM

18:56 RC36

Serum copeptin is not associated with asymptomatic peripheral artery disease in patients with type 1 diabetes

Lía Nattero-Chávez¹,³, María Ángeles Martínez-García³, Héctor F. Escobar-Morreale¹,³, Elena Fernández-Durán³, Sandra Redondo López2, Beatriz Dorado Avendaño¹, Manuel Luque-Ramírez¹,³

1Department of Endocrinology and Nutrition; 2 Department of Vascular Surgery; 3 Diabetes, Obesity and Human Reproduction Research Group, Hospital Universitario Ramón y Cajal & Universidad de Alcalá, Madrid & Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS) & CIBERDEM

14:45-15:45

SIMPOSIO SATÉLITE CIBERDEM/MSD 2020

Bienvenida: Eduard Montanya, Servicio de Endocrinología y Nutrición, Hospital Universitario de Bellvitge, Barcelona, Director Científico CIBERDEM

Moderador: Esteban Jodar, Jefe de servicio de Endocrinología y Nutrición, Hospitales Universitarios Quirón Salud Madrid

Los costes de la diabetes tipo 2: lecciones a partir de la base de datos poblacional SIDIAP en Catalunya

Manel Mata, Centro de Atención Primaria “La Mina”, Sant Adrià de Besòs, Barcelona; Grupo DAP-Cat de la Unitat de Suport a la Recerca de Barcelona Ciutat (Institut Universitari IDIAP-Jordi Gol); CIBERDEM; RedGDPS

Ver sesión

16:00-18:00

SESSION 5

Chair: Xavier Correig, Metabolomics Platform, Department of Electronic Engeniering (DEEEA), University Rovira i Virgili, Tarragona & Carlos Guillen, Universidad Complutense de Madrid

16:00-16:30

STATE OF THE ART LECTURE

Mitochondrial dynamics modulates phospholipid metabolism

Maribel Hernández, Instituto de Recerca Biomédica (IRB-Barcelona)

16:30-17:45

ORAL PRESENTATION

16:30 OP11

On-tissue metabolomics to describe the lipid composition of the atherosclerotic plaque in diabetic and non - diabetic patients

María García-Altares1,2, Esmeralda Castelblanco2,3, Lluc Sementé1, Pere Ràfols1, Óscar Yanes1,2, Dídac Mauricio2,3, Xavier Correig1,2

1 Metabolomics Platform, Department of Electronic Engeniering (DEEEA), University Rovira i Virgili, Tarragona; 2 CIBERDEM; 3 Research Institute of “Santa Cruz y San Pablo” Hospital, Barcelona

16:45 O12

Neuregulin 4 is required to preserve insulin action in adipocytes

Francisco Díaz-Sáez1,2, Marta Camps1,2, Antonio Zorzano1,3, Anna Gumà1,2

1Dept. Biochemistry and Molecular Biomedicine, Faculty of Biology, University of Barcelona; 2 Institute of Biomedicine of the University of Barcelona (IBUB), 3Institute of Biomedical Research-Barcelona (IRB-Barcelona)

17:00 O13

Succinate-consuming bacteria from human gut microbiota as probiotic treatment for obesity

Enrique Calvo, Isabel Huber-Ruano, Catalina Núñez-Roa, María del Mar Rodríguez, Noelia Keiran, Joan Sabadell-Basallote, Jesús Seco, Joan Vendrell, Sonia Fernández-Veledo.

Servei d’Endocrinologia i Nutrició i Unitat de Recerca, Hospital Universitari de Tarragona Joan XXIII, Institut d’Investigació Sanitària Pere Virgili (IISPV)

17:15 OP14

Epicardial adipose tissue secretome from type 2 diabetic patients contains more ceramides and induce inflammation and cytotoxicity in cardiomyocytes

José Luis Sánchez-Quesada, Nuria Puig, Ariadna Creus, Andrea Rivas-Urbina, Inka Miñambres, Pedro Gil, Francisco Blanco-Vaca, Antonio Pérez, Sonia Benítez.

Cardiovascular Biochemistry Group, Metabolic Basis of Cardiovascular Risk Group, and Endocrinology Department. Research Institute of the Hospital de Sant Pau, Barcelona

17:30 OP15

16:1-containing phosphatidylcholine reduces responses of macrophages to an inflammatory process

Miguel Ángel Bermúdez, María A. Balboa, Jesús Balsinde

Instituto de Biología y Genética Molecular (IBGM), Consejo Superior de Investigaciones Científicas (CSIC), Valladolid

18:00-19:00

SESSION 6 – RAPID COMUNICATIONS

Room 1

Chair: Anabel Rojas, CABIMER-Universidad Pablo Olavide, Sevilla & Izortze Santin, University of the Basque Country and Biocruces Health Research Institute

18:00 RC37

Role of ERα, ERβ and GPER1 on INS-1E β-cell line apoptosis

Ignacio Babiloni-Chust1, Laura Marroqui1,2, Reinaldo S. Dos Santos1,2, Medina-Galí R M1, 2, Ángel Nadal1, 2

1Centre: Instituto de Investigación, Desarrollo e Innovación en Biotecnología Sanitaria de Elche (IDiBE), Universidad Miguel Hernández de Elche, Elche; 2CIBERDEM

18:07 RC38

A T1D-associated lncRNA regulates the IRF7-driven inflammatory network (IDIN) in pancreatic beta cells.

Itziar González-Moro, Izortze Santin

University of the Basque Country and Biocruces Health Research Institute

18:14 RC39

Treatment of Type 1 diabetes in mice with a dual gene AAV vector encoding for insulin and glucokinase

Laia Vilà1,3, Marisa Jaén1,2,3, Verónica Jiménez1,2,3, Miquel García1,2,3, Ivet Elias1,2,3, Jordi Rodó1,2,3, Tura Ferré1,3, Fàtima Bosch1,2,3

1Center of Animal Biotechnology and Gene Therapy, 2Department of Biochemistry and Molecular Biology, Universitat Autònoma de Barcelona, 08193 Bellaterra; 3CIBERDEM

18:21 RC40

Distribution of seven apoC-III glycoforms in plasma, VLDL, IDL, LDL and HDL of healthy subjects and association with insulin resistance and the lipid profile

Pere Rehues, Marina Rodríguez, Víctor Iranzo, Jorge Mora, Clara Balsells, Montse Guardiola, Josep Ribalta

Unitat de Recerca en Lípids i Arteriosclerosi, Facultat de Medicina, Universitat Rovira i Virgili, Hospital Universitari de Sant Joan de Reus, Institut d’Investigació Sanitària Pere Virgili, CIBERDEM

18:28 RC41

Endocrine disruptors and type 2 diabetes: an integrated approach for hazard identification

Hilda Ferrero1,2, Ruba Al-Abdulla1, Paloma Alonso-Magdalena1,2

1Instituto de Investigación, Desarrollo e Innovación en Biotecnología Sanitaria de Elche (IDiBE), Universidad Miguel Hernández, Elche; 2CIBERDEM

18:35 RC42

Role of exosomes in pancreatic β-cells survival and potential link between T2DM and neurodegeneration

Jesús Burillo, Carlos González-Blanco, Beatriz Jiménez, Patricia Marqués, Gema García, Carlos Guillén, Manuel Benito

Facultad de Farmacia, Universidad Complutense de Madrid

18:42 RC43

Link between type 2 diabetes and Alzheimer's disease in Irs2 deficient mice

Carlos Acosta, Deborah Burks

Centro de Investigación Príncipe Felipe; CIBERDEM

Room 2

Chair: Mª Angeles Balboa, Instituto de Biología y Genética Molecular, CSIC, Valladolid & Joan Guinovart, Institut de Recerca Biomèdica (IRB), Barcelona

18:00 RC 44

GDF15 mediates the metabolic effects of metformin

David Aguilar-Recarte, Emma Barroso, Javier Pizarro-Delgado, Lucía Peña, Xavier Palomer, Manuel Vázquez-Carrera

Department of Pharmacology, Toxicology and Therapeutic Chemistry, Faculty of Pharmacy and Food Sciences and Institute of Biomedicine of the University of Barcelona (IBUB), University of Barcelona; CIBERDEM; Pediatric Research Institute-Hospital Sant Joan de Déu, Esplugues de Llobregat, Barcelona

18:07 RC45

Regulation of mitochondrial plasticity by Mfn2 drives metabolic flexibility

David Sebastián and Antonio Zorzano

Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Barcelona; Departament de Bioquímica i Biomedicina Molecular, Facultat de Biologia, Universitat de Barcelona; CIBERDEM

18:14 RC46

Unraveling the role of the insulin-degrading enzyme (IDE) on hepatic insulin and glucagon signaling

Carlos M. González-Casimiro, Beatriz Merino, Jesús Balsinde, Irene Cózar-Castellano, Germán Perdomo

Instituto de Biología y Genética Molecular (CSIC-UVa), Valladolid

18:21 RC47

SIRT3 deficiency exacerbates fatty liver by attenuating the HIF1α-lipin 1 pathway and increasing CD36 through Nrf2

Emma Barroso1,2,3, Rosalía Rodríguez-Rodríguez1,2,3, Mohammad Zarei1,2,3, Javier Pizarro-Degado1,2,3, Anna Planavila3,4,5, Xavier Palomer1,2,3, Francesc Villarroya3,4,5 and Manuel Vázquez-Carrera1,2,3

1Department of Pharmacology, Toxicology and Therapeutic Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, Institute of Biomedicine of the University of Barcelona (IBUB), Barcelona; 2CIBERDEM; 3Research Institute-Hospital Sant Joan de Déu; 4Department of Biochemistry and Molecular Biomedicine and IBUB, Faculty of Biology, University of Barcelona; 5 CIBEROBN.

18:28 RC48

Liver glycogen increases endurance capacity in mice

Iliana López-Soldado, Jordi Duran, Joan J. Guinovart

Institut de Recerca Biomèdica (IRB); CIBERDEM

18:35 RC49

Major genetic changes due to the disturbance of glycerolipid metabolism

Clara Meana, Javier Martínez-García, Jesus Balsinde, Mª Angeles Balboa

Instituto de Biología y Genética Molecular, Consejo Superior de Investigaciones Científicas (CSIC), Valladolid

18:42 RC50

Regulation of lipid levels by lipins and their impact on inflammatory processes

Álvaro Garrido, Patricia Monge, Jesús Balsinde, María A. Balboa

Instituto de Biología y Genética Molecular, CSIC, Valladolid, CIBERDEM

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